Support options for your patients

For eligible patients, Kyowa Kirin Cares can provide savings options.

Cost Savings for Eligible NOURIANZ Patients

Co-pay card program

Eligible patients may be able to fill their prescription for no more than $20 per month through the co-pay card program.

Co-pay card program terms and conditions

Commercial insurance

Kyowa Kirin offers co-pay assistance for eligible commercially insured patients. Review the co-pay assistance terms and conditions to determine if your patients with commercial insurance qualify.a,b

Government insurance

In most cases, Kyowa Kirin doesn’t offer a program for government- or military-insurance patients.c Patients may be eligible for assistance through independent charitable foundations.

No insurance

Kyowa Kirin offers a patient assistance program for eligible uninsured patients. Download the application to review the terms and conditions and determine if your patients with no insurance may qualify.c

aPatients must be US residents enrolled in an active primary commercial insurance plan; patients with federal or state government insurance such as Medicare, Medicaid, and Tricare are not eligible for co-pay assistance. Other terms and conditions may apply.

bCommercially insured patients do not need to participate in Kyowa Kirin Cares to be eligible for co-pay assistance.

cPatients must be US residents with no active medical or pharmacy benefit insurance and an annual gross income ≤400% of the federal poverty level, confirmed by electronic income verification response or documented proof of income.

Helpful forms and resources

Access Kyowa Kirin forms as well as useful NOURIANZ information and resources.

Consumer Brochure

Download the consumer brochure to help guide your patients through NOURIANZ treatment.

Letter of medical necessity

Download this template letter of medical necessity for appropriate patient cases.

Appeal letter

Find a sample letter here for patients who have been denied coverage.

Patient assistance program

Download the patient assistance program application for your uninsured patients.


Visit the NOURIANZ website to learn about efficacy, safety, dosing, and more.


NOURIANZ® (istradefylline) is an adenosine receptor antagonist indicated as adjunctive treatment to levodopa/carbidopa in adult patients with Parkinson’s disease (PD) experiencing “off” episodes.

Important Safety Information

Warnings and Precautions:

Dyskinesia: NOURIANZ in combination with levodopa may cause dyskinesia or exacerbate pre-existing dyskinesia. In clinical trials, 1% of patients treated with either NOURIANZ 20 mg or 40 mg discontinued treatment because of dyskinesia, compared to 0% for placebo.

Hallucinations / Psychotic Behavior: Because of the potential risk of exacerbating psychosis, patients with a major psychotic disorder should not be treated with NOURIANZ. Consider dosage reduction or discontinuation if a patient develops hallucinations or psychotic behaviors while taking NOURIANZ.

Impulse Control / Compulsive Behaviors: Patients treated with NOURIANZ and one or more medication(s) for the treatment of Parkinson’s disease (including levodopa) may experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge or compulsive eating, and/or other intense urges, and the inability to control these urges. In clinical trials, 1 patient treated with NOURIANZ 40 mg was reported to have impulse control disorder, compared to no patient on NOURIANZ 20 mg or placebo.

Drug Interactions:

The maximum recommended dosage in patients taking strong CYP3A4 inhibitors is 20 mg once daily. Avoid use of NOURIANZ with strong CYP3A4 inducers.

Specific Populations:

Pregnancy: Based on animal data, may cause fetal harm.

Hepatic impairment: The maximum recommended dosage of NOURIANZ in patients with moderate hepatic impairment is 20 mg once daily. Avoid use in patients with severe hepatic impairment.

Adverse Reactions:

The most common adverse reactions with an incidence ≥5% and occurring more frequently than with placebo were dyskinesia (15%, 17%, and 8%), dizziness (3%, 6%, and 4%), constipation (5%, 6%, and 3%), nausea (4%, 6%, and 5%), hallucination (2%, 6%, and 3%), and insomnia (1%, 6%, and 4%) for NOURIANZ 20 mg, 40 mg, and placebo, respectively.

You are encouraged to report suspected adverse reactions to Kyowa Kirin, Inc. at 1-844-768-3544 or FDA at 1-800-FDA-1088 or

Please see full Prescribing Information.